Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2), Truncated

Cat.No	ACP05281	Target Name	ADAMTS2
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	254-492aa	Mol Weight	32.2 kDa
Protein Length	Partial	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05281

Target Name

ADAMTS2

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

254-492aa

Mol Weight

32.2 kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O95450

Background Information

Uniprot Id

O95450
Target Species

Human
Target Name

ADAMTS2
Target Full Name

A disintegrin and metalloproteinase with thrombospondin motifs 2
Target Function

Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity.
Target Involvement

Ehlers-Danlos syndrome 7C (EDS7C)
Target Subcellular Location

Secreted, extracellular space, extracellular matrix.
Target Tissue Specificity

Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
Target Research Area

Cancer
Target Synonyms

A disintegrin and metalloproteinase with thrombospondin motifs 2; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2; ADAM metallopeptidase with thrombospondin type 1 motif 2; ADAM TS 2; ADAM TS2; ADAM-TS 2; ADAM-TS2; ADAMTS 3; ADAMTS-2; ADAMTS2; ATS2_HUMAN; EC 3.4.24.14; EDS VIIB; EDS VIIC; hPCPNI ; NPI ; PC I NP; PC I-NP; PCINP ; PCPNI ; pNPI; Procollagen I N proteinase; Procollagen I N-proteinase; Procollagen I/II amino propeptide processing enzyme; Procollagen I/II amino propeptide-processing enzyme; Procollagen N endopeptidase ; Procollagen N-endopeptidase
Target Background

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2), Truncated

Specifications

Immunogen Information

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