Recombinant Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1), Truncated

Uniprot Id

O60741

Target Species

Human

Target Name

HCN1

Target Full Name

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Target Function

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.

Target Involvement

Epileptic encephalopathy, early infantile, 24 (EIEE24)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Potassium channel HCN family

Target Tissue Specificity

Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas.

Target Synonyms

BCNG-1; BCNG1; Brain cyclic nucleotide gated channel 1; Brain cyclic nucleotide-gated channel 1; HAC 2; HAC2; HCN1; HCN1_HUMAN; Hyperpolarization activated cyclic nucleotide gated potassium channel 1; Potassium channel; voltage-gated; brain; 1; Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Target Background

The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes.