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| Cat.No | ACP05540 | Target Name | SCN4A |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P35499 |
|---|
Uniprot Id
P35499
Target Species
Human
Target Name
SCN4A
Target Full Name
Sodium channel protein type 4 subunit alpha
Target Function
Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states. Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels.
Target Involvement
Paramyotonia congenita of von Eulenburg (PMC); Periodic paralysis hypokalemic 2 (HOKPP2); Periodic paralysis hyperkalemic (HYPP); Periodic paralysis normokalemic (NKPP); Myotonia SCN4A-related (MYOSCN4A); Myasthenic syndrome, congenital, 16 (CMS16)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
Sodium channel (TC 1.A.1.10) family, Nav1.4/SCN4A subfamily
Target Synonyms
HYKPP; HYPP; Na(V)1.4; NAC1A; Nav1.4; Scn4a; SCN4A_HUMAN; Skeletal muscle voltage dependent sodium channel type IV alpha subunit ; SkM1; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type 4 subunit alpha; Sodium channel protein type IV subunit alpha; Sodium channel voltage gated type IV alpha subunit; Voltage gated sodium channel subunit alpha Nav1.4; Voltage gated sodium channel type 4 alpha ; Voltage-gated sodium channel subunit alpha Nav1.4
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