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Recombinant Human Sodium channel protein type 4 subunit alpha (SCN4A), Truncated

ACP05540

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP05540 Target NameSCN4A
FormLyophilized powderExpression SystemCustom Production. Please inquire and provide the desire expression system.
Protein LengthPartialPurity>85% (SDS-PAGE)
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDP35499
Background Information
  • Uniprot Id

    P35499

  • Target Species

    Human

  • Target Name

    SCN4A

  • Target Full Name

    Sodium channel protein type 4 subunit alpha

  • Target Function

    Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states. Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels.

  • Target Involvement

    Paramyotonia congenita of von Eulenburg (PMC); Periodic paralysis hypokalemic 2 (HOKPP2); Periodic paralysis hyperkalemic (HYPP); Periodic paralysis normokalemic (NKPP); Myotonia SCN4A-related (MYOSCN4A); Myasthenic syndrome, congenital, 16 (CMS16)

  • Target Subcellular Location

    Cell membrane; Multi-pass membrane protein.

  • Target Protein Families

    Sodium channel (TC 1.A.1.10) family, Nav1.4/SCN4A subfamily

  • Target Synonyms

    HYKPP; HYPP; Na(V)1.4; NAC1A; Nav1.4; Scn4a; SCN4A_HUMAN; Skeletal muscle voltage dependent sodium channel type IV alpha subunit ; SkM1; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type 4 subunit alpha; Sodium channel protein type IV subunit alpha; Sodium channel voltage gated type IV alpha subunit; Voltage gated sodium channel subunit alpha Nav1.4; Voltage gated sodium channel type 4 alpha ; Voltage-gated sodium channel subunit alpha Nav1.4

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