Recombinant Human Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), Truncated

Cat.No	ACP05617	Target Name	SLC4A4
Target Synonyms	brain type, kidney, member 4, sodium bicarbonate cotransporter	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05617

Target Name

SLC4A4

Target Synonyms

brain type, kidney, member 4, sodium bicarbonate cotransporter

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9Y6R1

Background Information

Uniprot Id

Q9Y6R1
Target Species

Human
Target Name

SLC4A4
Target Full Name

Electrogenic sodium bicarbonate cotransporter 1
Target Function

Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.; May have a higher activity than isoform 1.
Target Involvement

Renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
Target Subcellular Location

Basolateral cell membrane; Multi-pass membrane protein.
Target Protein Families

Anion exchanger (TC 2.A.31) family
Target Tissue Specificity

Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 i
Target Synonyms

DKFZp781H1314; Electrogenic sodium bicarbonate cotransporter 1; hhNMC; HNBC 1; HNBC1; kNBC 1; KNBC; kNBC1; Na(+)/HCO3(-) cotransporter; Na+HCO3- cotransporter 4; NBC 1; NBC 2; NBC1; NBC2; Nbc4; NBCE 1; NBCE1; OTTHUMP00000160355; OTTHUMP00000218884; OTTHUMP00000218885; PNBC; S4A4_HUMAN; SLC4A4; SLC4A5; Sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney, sodium bicarbonate cotransporter, pancreas); Sodium bicarbonate cotransporter; Sodium bicarbonate cotransporter kidney; sodium bicarbonate cotransporter member 4; Sodium bicarbonate cotransporter pancreas; Solute carrier family 4 member 4; Solute carrier family 4 sodium bicarbonate cotransporter member 4; Solute carrier family 4 sodium bicarbonate cotransporter member 5; Solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type
Target Background

This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), Truncated Now

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