Recombinant Human Sodium channel protein type 8 subunit alpha (SCN8A), Truncated

Cat.No	ACP05629	Target Name	SCN8A
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05629

Target Name

SCN8A

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9UQD0

Background Information

Uniprot Id

Q9UQD0
Target Species

Human
Target Name

SCN8A
Target Full Name

Sodium channel protein type 8 subunit alpha
Target Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.; In macrophages and melanoma cells, may participate in the control of podosome and invadopodia formation.
Target Involvement

Cognitive impairment with or without cerebellar ataxia (CIAT); Epileptic encephalopathy, early infantile, 13 (EIEE13); Seizures, benign familial infantile, 5 (BFIS5)
Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell projection, axon.; [Isoform 5]: Cytoplasmic vesicle. Note=Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane.
Target Protein Families

Sodium channel (TC 1.A.1.10) family, Nav1.6/SCN8A subfamily
Target Tissue Specificity

Expressed in the hippocampus with increased expression in epileptic tissue compared to normal adjacent tissue (at protein level). Isoform 5: Expressed in non-neuronal tissues, such as monocytes/macrophages.
Target Synonyms

CerIII; CIAT; EIEE13; hNa6/Scn8a voltage gated sodium channel; MED; Motor endplate disease; NaCh 6; NaCh6; Nav 1.6; Nbna1; peripheral nerve protein type 4; PN 4; PN4; SCN8A; SCN8A_HUMAN; Sodium channel protein type 8 alpha subunit; Sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII alpha subunit; Sodium channel protein type VIII subunit alpha; Sodium channel voltage gated type VIII alpha; Sodium channel voltage gated type VIII alpha polypeptide; Sodium channel voltage gated type VIII alpha subunit; Voltage gated sodium channel subunit alpha Nav1.6; Voltage-gated sodium channel subunit alpha Nav1.6

Recombinant Human Sodium channel protein type 8 subunit alpha (SCN8A), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Sodium channel protein type 8 subunit alpha (SCN8A), Truncated Now

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