Recombinant Human Rhomboid-related protein 2 (RHBDL2), Truncated

Uniprot Id

Q9NX52

Target Species

Human

Target Name

RHBDL2

Target Full Name

Rhomboid-related protein 2

Target Function

Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.

Target Subcellular Location

[Rhomboid-related protein 2, C-terminal fragment]: Cell membrane; Multi-pass membrane protein.

Target Protein Families

Peptidase S54 family

Target Research Area

Others

Target Synonyms

RHBDL2; Rhomboid-related protein 2; RRP2; EC 3.4.21.105; Rhomboid-like protein 2) [Cleaved into: Rhomboid-related protein 2; N-terminal fragment; NTF); Rhomboid-related protein 2; C-terminal fragment; CTF)]

Target Background

The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. Two transcript variants encoding different isoforms have been found for this gene.