Recombinant Human Solute carrier family 15 member 4 (SLC15A4), Truncated

Cat.No	ACP05889	Target Name	SLC15A4
Target Synonyms	SLC15A4; PHT1; PTR4; FP12591; Solute carrier family 15 member 4; Peptide transporter 4; Peptide/histidine transporter 1; hPHT1	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05889

Target Name

SLC15A4

Target Synonyms

SLC15A4; PHT1; PTR4; FP12591; Solute carrier family 15 member 4; Peptide transporter 4; Peptide/histidine transporter 1; hPHT1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8N697

Background Information

Uniprot Id

Q8N697
Target Species

Human
Target Name

SLC15A4
Target Full Name

Solute carrier family 15 member 4
Target Function

Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response. Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans. Transporter activity is pH-dependent and maximized in the acidic lysosomal environment. Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5. Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation. Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses.
Target Subcellular Location

Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Target Protein Families

PTR2/POT transporter (TC 2.A.17) family
Target Tissue Specificity

Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) a
Target Synonyms

SLC15A4; PHT1; PTR4; FP12591; Solute carrier family 15 member 4; Peptide transporter 4; Peptide/histidine transporter 1; hPHT1

Recombinant Human Solute carrier family 15 member 4 (SLC15A4), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Solute carrier family 15 member 4 (SLC15A4), Truncated Now

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