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| Cat.No | ACP06064 | Target Name | OTOP1 |
|---|---|---|---|
| Target Synonyms | OTOP1; Proton channel OTOP1; Otopetrin-1; hOtop1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q7RTM1 |
|---|
Uniprot Id
Q7RTM1
Target Species
Human
Target Name
OTOP1
Target Full Name
Proton channel OTOP1
Target Function
Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly-sensitive to voltage. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration. Probably acts by maintaining the pH appropriate for formation of otoconia. Regulates purinergic control of intracellular calcium in vestibular supporting cells. May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol. Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
Otopetrin family
Target Synonyms
OTOP1; Proton channel OTOP1; Otopetrin-1; hOtop1
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