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| Cat.No | ACP06280 | Target Name | HGSNAT |
|---|---|---|---|
| Target Synonyms | HGSNAT; TMEM76; Heparan-alpha-glucosaminide N-acetyltransferase; EC 2.3.1.78; Transmembrane protein 76 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q68CP4 |
|---|
Uniprot Id
Q68CP4
Target Species
Human
Target Name
HGSNAT
Target Full Name
Heparan-alpha-glucosaminide N-acetyltransferase
Target Function
Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase.
Target Involvement
Mucopolysaccharidosis 3C (MPS3C); Retinitis pigmentosa 73 (RP73)
Target Subcellular Location
Lysosome membrane; Multi-pass membrane protein. Note=Colocalizes with the lysosomal marker LAMP2. The signal peptide is not cleaved upon translocation into the endoplasmic reticulum; the precursor is probably targeted to the lysosomes via the adapter protein complex-mediated pathway that involves tyrosine- and/or dileucine-based conserved amino acid motifs in the last C-terminus 16-amino acid domain.
Target Tissue Specificity
Widely expressed, with highest level in leukocytes, heart, liver, skeletal muscle, lung, placenta and liver.
Target Synonyms
HGSNAT; TMEM76; Heparan-alpha-glucosaminide N-acetyltransferase; EC 2.3.1.78; Transmembrane protein 76
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