Recombinant Human Kunitz-type protease inhibitor 2 (SPINT2), Truncated

Uniprot Id

O43291

Target Species

Human

Target Name

SPINT2

Target Full Name

Kunitz-type protease inhibitor 2

Target Function

Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.

Target Involvement

Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies (DIAR3)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.

Target Synonyms

SPINT2; HAI2; KOP; Kunitz-type protease inhibitor 2; Hepatocyte growth factor activator inhibitor type 2; HAI-2; Placental bikunin

Target Background

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.