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| Cat.No | ACP06346 | Target Name | SCN2B |
|---|---|---|---|
| Target Synonyms | SCN2B; UNQ326/PRO386; Sodium channel subunit beta-2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O60939 |
|---|
Uniprot Id
O60939
Target Species
Human
Target Name
SCN2B
Target Full Name
Sodium channel regulatory subunit beta-2
Target Function
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.
Target Involvement
Atrial fibrillation, familial, 14 (ATFB14)
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Sodium channel auxiliary subunit SCN2B (TC 8.A.17) family
Target Tissue Specificity
Brain specific.
Target Synonyms
SCN2B; UNQ326/PRO386; Sodium channel subunit beta-2
Target Background
The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome.
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