Recombinant Human Translocon-associated protein subunit alpha (SSR1), Truncated

Uniprot Id

P43307

Target Species

Human

Target Name

SSR1

Target Full Name

Translocon-associated protein subunit alpha

Target Function

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Target Protein Families

TRAP-alpha family

Target Synonyms

SSR1; TRAPA; PSEC0262; Translocon-associated protein subunit alpha; TRAP-alpha; Signal sequence receptor subunit alpha; SSR-alpha

Target Background

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene.