Recombinant Human Interleukin-3 receptor subunit alpha (IL3RA), Truncated

Uniprot Id

P26951

Target Species

Human

Target Name

IL3RA

Target Full Name

Interleukin-3 receptor subunit alpha

Target Function

This is a receptor for interleukin-3.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Type I cytokine receptor family, Type 5 subfamily

Target Synonyms

IL3RA; IL3R; Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD antigen CD123

Target Background

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.