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The antibody against SREBF2 was raised in rabbit using the Recombinant Human Sterol regulatory element-binding protein 2 protein (75-164AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against SREBF2 was raised in rabbit using the Recombinant Human Sterol regulatory element-binding protein 2 protein (75-164AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
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| Cat.No | ADC-08758A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SREBF2 |
| Target Synonyms | SREBF2; BHLHD2; SREBP2; Sterol regulatory element-binding protein 2; SREBP-2; Class D basic helix-loop-helix protein 2; bHLHd2; Sterol regulatory element-binding transcription factor 2 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | FITC conjugated | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Sterol regulatory element-binding protein 2 protein (75-164AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q12772 |
Uniprot Id
Q12772
Target Species
Human
Target Name
SREBF2
Target Full Name
Sterol regulatory element-binding protein 2
Target Function
Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis.; Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates transcription of genes related to cholesterol synthesis pathway.
Target Subcellular Location
[Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.; [Processed sterol regulatory element-binding protein 2]: Nucleus.
Target Protein Families
SREBP family
Target Tissue Specificity
Ubiquitously expressed in adult and fetal tissues.
Target Synonyms
SREBF2; BHLHD2; SREBP2; Sterol regulatory element-binding protein 2; SREBP-2; Class D basic helix-loop-helix protein 2; bHLHd2; Sterol regulatory element-binding transcription factor 2
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