Recombinant Human Voltage-dependent calcium channel gamma-2 subunit (CACNG2), Truncated

Uniprot Id

Q9Y698

Target Species

Human

Target Name

CACNG2

Target Full Name

Voltage-dependent calcium channel gamma-2 subunit

Target Function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

Target Involvement

Mental retardation, autosomal dominant 10 (MRD10)

Target Subcellular Location

Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Target Protein Families

PMP-22/EMP/MP20 family, CACNG subfamily

Target Tissue Specificity

Brain.

Target Synonyms

CACNG2; Voltage-dependent calcium channel gamma-2 subunit; Neuronal voltage-gated calcium channel gamma-2 subunit; Transmembrane AMPAR regulatory protein gamma-2; TARP gamma-2

Target Background

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. The AMPA subtype of ionotropic glutamate receptors are ligand gated ion channels that are typically activated by glutamate released from presynaptic neuron terminals and mediate fast neurotransmission in excitatory synapses. TARPs thus play an important role in synaptic plasticity, learning and memory. Mutations in this gene cause an autosomal dominant form of cognitive disability.