Recombinant Human LEM domain-containing protein 2 (LEMD2), Truncated

Uniprot Id

Q8NC56

Target Species

Human

Target Name

LEMD2

Target Full Name

LEM domain-containing protein 2

Target Function

Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope.; Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT. Required for myoblast differentiation involving regulation of ERK signaling.

Target Involvement

Cataract 46, juvenile-onset (CTRCT46)

Target Subcellular Location

Nucleus inner membrane; Multi-pass membrane protein. Note=Lamina-associated protein residing in the inner nuclear membrane (INM). Localized exclusively to the nuclear envelope, giving rise to a typical rim-like staining of the nuclear periphery.

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

LEMD2; LEM domain-containing protein 2; hLEM2

Target Background

This gene encodes a LEM domain-containing transmembrane protein of the inner nuclear membrane. The protein is involved in nuclear structure organization and plays a role in cell signaling and differentiation. Mutations in this gene result in Cataract 46, juvenile-onset. Multiple transcript variants have been found for this gene.