Recombinant Human 5-hydroxytryptamine receptor 4 (HTR4), Truncated

Uniprot Id

Q13639

Target Species

Human

Target Name

HTR4

Target Full Name

5-hydroxytryptamine receptor 4

Target Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Endosome.

Target Protein Families

G-protein coupled receptor 1 family

Target Tissue Specificity

Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle.

Target Synonyms

HTR4; 5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; Serotonin receptor 4

Target Background

This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.