Recombinant Human Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2)

Uniprot Id

Q9Y5Y2

Target Species

Human

Target Name

NUBP2

Target Full Name

Cytosolic Fe-S cluster assembly factor NUBP2

Target Function

Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.

Target Subcellular Location

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center.

Target Protein Families

Mrp/NBP35 ATP-binding proteins family, NUBP2/CFD1 subfamily

Target Tissue Specificity

Widely expressed with highest expression in skeletal muscle.

Target Synonyms

C447E6.1 (nucleotide binding protein 1 (E.coli MinD like) ); CFD1; Cytosolic Fe-S cluster assembly factor NUBP2; D17Wsu11e; Homolog of yeast cytosolic FeS cluster deficient 1; NBP 2; NUBP1; Nubp2; NUBP2_HUMAN; Nucleotide binding protein 2 (E.coli MinD like); Nucleotide binding protein 2 (MinD homolog, E. coli); Nucleotide binding protein 2; Nucleotide-binding protein 2

Target Background

This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants.