Recombinant Human DnaJ homolog subfamily B member 4 (DNAJB4)

Uniprot Id

Q9UDY4

Target Species

Human

Target Name

DNAJB4

Target Full Name

DnaJ homolog subfamily B member 4

Target Function

Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).

Target Subcellular Location

Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.

Target Tissue Specificity

Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.

Target Synonyms

DjB4; DnaJ (Hsp40) homolog subfamily B member 4; DnaJ homolog subfamily B member 4; DnaJ like heat shock protein 40; DNAJB 4; DNAJB4; DNAJW; DNJB4_HUMAN; Heat shock 40 kDa protein 1 homolog; Heat shock protein 40 homolog; HLJ 1; HLJ1; HSP40 homolog; Human liver DnaJ-like protein

Target Background

The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene.