Recombinant Human Testis-specific Y-encoded-like protein 2 (TSPYL2)

Uniprot Id

Q9H2G4

Target Species

Human

Target Name

TSPYL2

Target Full Name

Testis-specific Y-encoded-like protein 2

Target Function

Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

Nucleosome assembly protein (NAP) family

Target Tissue Specificity

Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.

Target Synonyms

CASK interacting nucleosome assembly protein; CDA1; Cell division autoantigen 1; Cell division autoantigen 1 nucleolar protein; CTCL tumor antigen se20-4; CTCL-associated antigen se20-4; Cutaneous T-cell lymphoma-associated antigen se20-4; DENTT; Differentially-expressed nucleolar TGF-beta1 target protein; HRIHFB2216; NP79; Nuclear protein of 79 kDa; Testis-specific Y-encoded-like protein 2; TSPX; TSPY-like protein 2; TSPYL2; TSYL2_HUMAN

Target Background

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth.