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The antibody against DEFB126 was raised in rabbit using the Recombinant Human Beta-defensin 126 protein (36-111AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against DEFB126 was raised in rabbit using the Recombinant Human Beta-defensin 126 protein (36-111AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using DEFB126 Antibody at dilution of 1:100
| Cat.No | ADC-09014A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DEFB126 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Beta-defensin 126 protein (36-111AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BYW3 |
Uniprot Id
Q9BYW3
Target Species
Human
Target Name
DEFB126
Target Full Name
Beta-defensin 126
Target Function
Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte. In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation.
Target Involvement
May be involved in infertility. Homozygosity for frameshift truncating mutations are associated with reduced sperm O-linked glycan content, impaired sperm mobility and a reduced live birth rate (PubMed:21775668, PubMed:25721098). However, for one common mutation the change in sperm sialic acid levels has been challenged (PubMed:26832966).
Target Subcellular Location
Secreted.
Target Protein Families
Beta-defensin family
Target Tissue Specificity
High-level and epididymis-specific expression. Expression is down-regulated in infertile men.
Target Synonyms
DEFB126; C20orf8; DEFB26Beta-defensin 126; Beta-defensin 26; DEFB-26; Defensin; beta 126; Epididymal secretory protein 13.2; ESP13.2; HBD26
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