Recombinant Human Kelch domain-containing protein 5 (KLHDC5)

Uniprot Id

Q9P2K6

Target Species

Human

Target Name

KLHL42

Target Full Name

Kelch-like protein 42

Target Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles. During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis.

Target Synonyms

KLHL42; KIAA1340; KLHDC5Kelch-like protein 42; Cullin-3-binding protein 9; Ctb9; Kelch domain-containing protein 5

Target Background

Contributes to ubiquitin-protein transferase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of microtubule-based process. Part of Cul3-RING ubiquitin ligase complex.