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| Cat.No | ACP10549 | Target Name | SDHAF2 |
|---|---|---|---|
| Target Synonyms | mitochondrial; Succinate dehydrogenase subunit 5 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 30-166 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NX18 |
|---|
Uniprot Id
Q9NX18
Target Species
Human
Target Name
SDHAF2
Target Full Name
Succinate dehydrogenase assembly factor 2, mitochondrial
Target Function
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
Target Involvement
Paragangliomas 2 (PGL2)
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
SDHAF2 family
Target Synonyms
Chromosome 11 open reading frame 79; FLJ20487; hSDH5; mitochondrial; Paraganglioma or familial glomus tumors 2; PGL2; SDH assembly factor 2; SDH5; Sdhaf2; SDHF2_HUMAN; Succinate dehydrogenase assembly factor 2, mitochondrial; Succinate dehydrogenase subunit 5
Target Background
This gene encodes a mitochondrial assembly factor needed for the flavination of a succinate dehydrogenase complex subunit (SDHA), which is required for activity of the succinate dehydrogenase complex. Mutations in this gene are associated with paraganglioma.
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