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| Cat.No | ACP10997 | Target Name | C12orf65 |
|---|---|---|---|
| Target Synonyms | C12orf65; My030Probable peptide chain release factor C12orf65; mitochondrial | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 36-166 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H3J6 |
|---|
Uniprot Id
Q9H3J6
Target Species
Human
Target Name
MTRFR
Target Full Name
Mitochondrial translation release factor in rescue
Target Function
Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue.
Target Involvement
Combined oxidative phosphorylation deficiency 7 (COXPD7); Spastic paraplegia 55, autosomal recessive (SPG55)
Target Subcellular Location
Mitochondrion.
Target Protein Families
Prokaryotic/mitochondrial release factor family
Target Tissue Specificity
Expressed in all areas of the brain tested.
Target Synonyms
C12orf65; My030Probable peptide chain release factor C12orf65; mitochondrial
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