Recombinant Human NKG2D ligand 2 (ULBP2)

Uniprot Id

Q9BZM5

Target Species

Human

Target Name

ULBP2

Target Full Name

UL16-binding protein 2

Target Function

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Secreted.

Target Protein Families

MHC class I family

Target Tissue Specificity

Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.

Target Synonyms

ALCAN alpha; ALCAN-alpha; N2DL 2; N2DL-2; N2DL2; N2DL2_HUMAN; NKG2D ligand 2; NKG2D ligand 2 precursor; NKG2DL2; RAET1H; Retinoic acid early transcript 1 H; Retinoic acid early transcript 1H; UL16 binding protein 2; UL16-binding protein 2; ULBP2

Target Background

This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6.