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| Cat.No | ACP11056 | Target Name | AMN |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BXJ7 |
|---|
Uniprot Id
Q9BXJ7
Target Species
Human
Target Name
AMN
Target Full Name
Protein amnionless
Target Function
Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface. The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12. Required for normal CUBN-mediated protein transport in the kidney (Probable).
Target Involvement
Recessive hereditary megaloblastic anemia 1 (RH-MGA1)
Target Subcellular Location
[Isoform 1]: Apical cell membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Endosome membrane. Membrane, coated pit.; [Soluble protein amnionless]: Secreted.
Target Tissue Specificity
Detected in proximal tubules in the kidney cortex (at protein level). Long isoforms are highly expressed in small intestine, colon and kidney (renal proximal tubule epithelial cells). Shorter isoforms are detected at lower levels in testis, thymus and per
Target Synonyms
5033428N14Rik; amn; Amnion associated transmembrane protein; Amnionless; Amnionless homolog; AMNLS_HUMAN; AV002116; PRO1028; Protein amnionless; Type I transmembrane protein; UNQ513/PRO1028; Visceral endoderm specific type 1 transmembrane protein
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