Recombinant Human Group IIE secretory phospholipase A2 (PLA2G2E)

Cat.No	ACP11401	Target Name	PLA2G2E
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	20-142	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP11401

Target Name

PLA2G2E

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

20-142

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NZK7

Background Information

Uniprot Id

Q9NZK7
Target Species

Human
Target Name

PLA2G2E
Target Full Name

Group IIE secretory phospholipase A2
Target Function

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), releasing various unsaturated fatty acids including oleoate, linoleoate, arachidonate, docosahexaenoate and lysophosphatidylethanolamines in preference to lysophosphatidylcholines. In response to high-fat diet, hydrolyzes minor lipoprotein phospholipids including phosphatidylserines, phosphatidylinositols and phosphatidylglycerols, altering lipoprotein composition and fat storage in adipose tissue and liver. May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria. Acts as a hair follicle phospholipase A2. Selectively releases lysophosphatidylethanolamines (LPE) and various unsaturated fatty acids in skin to regulate hair follicle homeostasis. May regulate the inflammatory response by releasing arachidonate, a precursor of prostaglandins and leukotrienes. Upon allergen exposure, may participate in allergic inflammatory response by enhancing leukotriene C4 synthesis and degranulation in mast cells
Target Subcellular Location

Secreted. Cytoplasm.
Target Protein Families

Phospholipase A2 family
Target Tissue Specificity

Restricted to the brain, heart, lung, and placenta.
Target Synonyms

2IIE; GIIE sPLA2; Group IIE secretory phospholipase A2; Group IIE secretory phospholipase A2 precursor ; PA2GE_HUMAN; Phosphatidylcholine 2 acylhydrolase GIIE ; Phosphatidylcholine 2-acylhydrolase 2E; Phospholipase A2 group IIE ; Phospholipase A2 IIE; Pla2g2e; sPLA ; sPLA2-IIE

Recombinant Human Group IIE secretory phospholipase A2 (PLA2G2E)

Specifications

Immunogen Information

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