Recombinant Human Mitochondrial nucleoid factor 1 (MNF1)

Uniprot Id

Q9BRT2

Target Species

Human

Target Name

UQCC2

Target Full Name

Ubiquinol-cytochrome c reductase complex assembly factor 2

Target Function

Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability.

Target Involvement

Mitochondrial complex III deficiency, nuclear 7 (MC3DN7)

Target Subcellular Location

Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion. Mitochondrion intermembrane space. Mitochondrion matrix. Mitochondrion inner membrane.

Target Tissue Specificity

Pancreas, skeletal muscle, kidney, liver and heart.

Target Synonyms

UQCC2; C6orf125; MNF1; Ubiquinol-cytochrome-c reductase complex assembly factor 2; Breast cancer-associated protein SGA-81M; Mitochondrial nucleoid factor 1; Mitochondrial protein M19

Target Background

This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity.