Recombinant Human DnaJ homolog subfamily B member 9 (DNAJB9)

Cat.No	ACP11949	Target Name	DNAJB9
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	24-223	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP11949

Target Name

DNAJB9

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

24-223

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9UBS3

Background Information

Uniprot Id

Q9UBS3
Target Species

Human
Target Name

DNAJB9
Target Full Name

DnaJ homolog subfamily B member 9
Target Function

Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.
Target Subcellular Location

Endoplasmic reticulum lumen.
Target Tissue Specificity

Widely expressed. Expressed at highest level in the liver, placenta and kidney.
Target Synonyms

DKFZP564F1862; DnaJ (Hsp40) homolog subfamily B member 9; DnaJ homolog subfamily B member 9; DNAJB9; DNJB9_HUMAN; eEndoplasmic reticulum DNA J domain containing protein 4; Endoplasmic reticulum DnaJ homolog 4; ER resident protein ERdj4; ERdj4; MDG 1; Mdg-1; MDG1; Microvascular endothelial differentiation gene 1; Microvascular endothelial differentiation gene 1 protein; MST049; MSTP049; OTTHUMP00000206840
Target Background

This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis.

Recombinant Human DnaJ homolog subfamily B member 9 (DNAJB9)

Specifications

Immunogen Information

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