Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22), Truncated

Uniprot Id

Q9P0K1

Target Species

Human

Target Name

ADAM22

Target Full Name

Disintegrin and metalloproteinase domain-containing protein 22

Target Function

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell projection, axon.

Target Tissue Specificity

Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues.

Target Synonyms

A disintegrin and metalloproteinase domain 22; ADA22_HUMAN; ADAM 22; ADAM metallopeptidase domain 22; adam22; and cysteine-rich protein 2; Disintegrin and metalloproteinase domain-containing protein 22; disintegrin-like; MDC 2; MDC2; Metalloproteinase disintegrin ADAM22 3; Metalloproteinase like disintegrin like and cysteine rich protein 2; Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like; MGC149832

Target Background

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.