Recombinant Human 39S ribosomal protein L44, mitochondrial (MRPL44)

Uniprot Id

Q9H9J2

Target Species

Human

Target Name

MRPL44

Target Full Name

Large ribosomal subunit protein mL44

Target Function

Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.

Target Involvement

Combined oxidative phosphorylation deficiency 16 (COXPD16)

Target Subcellular Location

Mitochondrion.

Target Protein Families

Ribonuclease III family, Mitochondrion-specific ribosomal protein mL44 subfamily

Target Synonyms

MRPL44; 39S ribosomal protein L44; mitochondrial; L44mt; MRP-L44; EC 3.1.26.-; Mitochondrial large ribosomal subunit protein mL44

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.