Recombinant Human Cytoplasmic polyadenylation element-binding protein 1 (CPEB1)

Uniprot Id

Q9BZB8

Target Species

Human

Target Name

CPEB1

Target Full Name

Cytoplasmic polyadenylation element-binding protein 1

Target Function

Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry.

Target Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, P-body. Cytoplasmic granule. Cell junction, synapse. Membrane. Cell junction, synapse, postsynaptic density. Cell projection, dendrite.

Target Protein Families

RRM CPEB family

Target Tissue Specificity

Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart. Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

CEBP; CPE binding protein 1; CPE BP1; CPE-binding protein 1; CPE-BP1; CPEB 1; CPEB; CPEB-1; CPEB1; CPEB1 protein; CPEB1_HUMAN; Cytoplasmic polyadenylation binding protein 1; Cytoplasmic polyadenylation element binding protein; Cytoplasmic polyadenylation element binding protein 1; Cytoplasmic polyadenylation element-binding protein 1; FLJ13203; h CEBP; h-CEBP; hCPEB 1; hCPEB-1; MGC34136; MGC60106; mKIAA0940; MKIAA0940 protein

Target Background

This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants.