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Recombinant Human Nogo-B receptor (NUS1), Truncated

ACP13807

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Specifications

Cat.No	ACP13807	Target Name	NUS1
Target Synonyms	C6orf68; MGC:7199; NgBR; NGBR_HUMAN; Nogo-B receptor; Nuclear undecaprenyl pyrophosphate synthase 1 homolog; nus1; TANGO14; Transport and golgi organization 14 homolog	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q96E22

Background Information

Uniprot Id

Q96E22
Target Species

Human
Target Name

NUS1
Target Full Name

Dehydrodolichyl diphosphate synthase complex subunit NUS1
Target Function

With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator.
Target Involvement

Congenital disorder of glycosylation 1AA (CDG1AA)
Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families

UPP synthase family
Target Synonyms

C6orf68; MGC:7199; NgBR; NGBR_HUMAN; Nogo-B receptor; Nuclear undecaprenyl pyrophosphate synthase 1 homolog; nus1; TANGO14; Transport and golgi organization 14 homolog

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Recombinant Human Nogo-B receptor (NUS1), Truncated

Specifications

Immunogen Information

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