Recombinant Human Centromere protein S (APITD1)

Cat.No	ACP14014	Target Name	CENPS
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-138	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP14014

Target Name

CENPS

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-138

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8N2Z9

Background Information

Uniprot Id

Q8N2Z9
Target Species

Human
Target Name

CENPS
Target Full Name

Centromere protein S
Target Function

DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own
Target Subcellular Location

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
Target Protein Families

TAF9 family, CENP-S/MHF1 subfamily
Target Tissue Specificity

Ubiquitously expressed.
Target Synonyms

APITD1; Apoptosis-inducing TAF9-like domain-containing protein 1; apoptosis-inducing; TAF9-like domain 1; CENP-S; CENPS; CENPS_HUMAN; Centromere protein S; FAAP16; FANCM-interacting histone fold protein 1; Fanconi anemia-associated polypeptide of 16 kDa; MGC32686; MHF 1

Recombinant Human Centromere protein S (APITD1)

Specifications

Immunogen Information

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