Recombinant Human Transcription factor IIIA (GTF3A)

Uniprot Id

Q92664

Target Species

Human

Target Name

GTF3A

Target Full Name

Transcription factor IIIA

Target Function

Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes. Also binds the transcribed 5S RNA's.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Ubiquitous.

Target Synonyms

AP 2; AP2; Factor A; General transcription factor 3A; General transcription factor IIIA; GTF 3A; GTF3A; TF3A_HUMAN; TFIIIA; Transcription factor 3A; Transcription factor IIIA

Target Background

The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein.