Recombinant Human Ribonuclease H2 subunit C (RNASEH2C)

Uniprot Id

Q8TDP1

Target Species

Human

Target Name

RNASEH2C

Target Full Name

Ribonuclease H2 subunit C

Target Function

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.

Target Involvement

Aicardi-Goutieres syndrome 3 (AGS3)

Target Subcellular Location

Nucleus.

Target Protein Families

RNase H2 subunit C family

Target Tissue Specificity

Widely expressed.

Target Synonyms

RNASEH2C; AYP1; Ribonuclease H2 subunit C; RNase H2 subunit C; Aicardi-Goutieres syndrome 3 protein; AGS3; RNase H1 small subunit; Ribonuclease HI subunit C

Target Background

This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene.