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| Cat.No | ACP14261 | Target Name | SPC24 |
|---|---|---|---|
| Target Synonyms | FLJ90806; hSpc24; Kinetochore protein Spc24; SPBC24; spc24; SPC24 NDC80 kinetochore complex component; SPC24 NDC80 kinetochore complex component homolog; SPC24, homolog (S. cerevisiae); SPC24_HUMAN; Spindle pole body component 24 homolog (S. cerevisiae); Spindle pole body component 24 homolog, NDC80 kinetochore complex component | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-197 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NBT2 |
|---|
Uniprot Id
Q8NBT2
Target Species
Human
Target Name
SPC24
Target Full Name
Kinetochore protein Spc24
Target Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Target Subcellular Location
Nucleus. Chromosome, centromere, kinetochore.
Target Protein Families
SPC24 family
Target Synonyms
FLJ90806; hSpc24; Kinetochore protein Spc24; SPBC24; spc24; SPC24 NDC80 kinetochore complex component; SPC24 NDC80 kinetochore complex component homolog; SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); SPC24_HUMAN; Spindle pole body component 24 homolog (S. cerevisiae); Spindle pole body component 24 homolog
Target Background
Predicted to be involved in cell division. Located in nucleolus and nucleoplasm. Part of Ndc80 complex.
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