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| Cat.No | ACP14434 | Target Name | UTP4 |
|---|---|---|---|
| Target Synonyms | UTP4; CIRH1A; cPERP-E; KIAA1988U3 small nucleolar RNA-associated protein 4 homolog; Cirhin; UTP4 small subunit processome component | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-686 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q969X6 |
|---|
Uniprot Id
Q969X6
Target Species
Human
Target Name
UTP4
Target Full Name
U3 small nucleolar RNA-associated protein 4 homolog
Target Function
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV.
Target Subcellular Location
Nucleus, nucleolus. Chromosome.
Target Synonyms
UTP4; CIRH1A; cPERP-E; KIAA1988U3 small nucleolar RNA-associated protein 4 homolog; Cirhin; UTP4 small subunit processome component
Target Background
This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. Alternative splicing results in multiple transcript variants.
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