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The antibody against KDM6B was raised in rabbit using the Recombinant Human Lysine-specific demethylase 6B protein (1530-1682AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against KDM6B was raised in rabbit using the Recombinant Human Lysine-specific demethylase 6B protein (1530-1682AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
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Immunofluorescent analysis of Hela cells using KDM6B Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-09292A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KDM6B |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Lysine-specific demethylase 6B protein (1530-1682AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O15054 |
Uniprot Id
O15054
Target Species
Human
Target Name
KDM6B
Target Full Name
Lysine-specific demethylase 6B
Target Function
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex.
Target Subcellular Location
Nucleus.
Target Protein Families
UTX family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Histone demethylase JMJD3; JmjC domain containing protein 3; JmjC domain-containing protein 3; Jumonji D3; Jumonji domain containing 3; Jumonji domain containing 3 histone lysine demethylase; Jumonji domain containing protein 3; Jumonji domain-containing protein 3; Kdm6b; KDM6B_HUMAN; KIAA0346; Lysine demethylase 6B; Lysine K specific demethylase 6B; Lysine specific demethylase 6B ; Lysine-specific demethylase 6B
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