Recombinant Human Notch-regulated ankyrin repeat-containing protein (NRARP)

Uniprot Id

Q7Z6K4

Target Species

Human

Target Name

NRARP

Target Full Name

Notch-regulated ankyrin repeat-containing protein

Target Function

Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal. Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis. During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain.

Target Protein Families

NRARP family

Target Synonyms

MGC61598; Notch regulated ankyrin repeat containing protein; NOTCH regulated ankyrin repeat protein; Notch-regulated ankyrin repeat-containing protein; nrarp; NRARP_HUMAN

Target Background

Involved in Notch signaling pathway. Acts upstream of or within negative regulation of Notch signaling pathway and positive regulation of canonical Wnt signaling pathway.