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| Cat.No | ACP15603 | Target Name | KANSL1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q7Z3B3 |
|---|
Uniprot Id
Q7Z3B3
Target Species
Human
Target Name
KANSL1
Target Full Name
KAT8 regulatory NSL complex subunit 1
Target Function
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
Target Subcellular Location
Nucleus. Nucleus. Chromosome, centromere, kinetochore.
Target Tissue Specificity
Expressed in the brain.
Target Synonyms
CENP-36; centromere protein 36; DKFZp686P06109; DKFZp727C091; hMSL1v1; hypothetical protein LOC284058; K1267_HUMAN; KANSL1; KAT8 regulatory NSL complex subunit 1; KDVS; KIAA1267; male-specific lethal 1 homolog; MGC102843; MLL1/MLL complex subunit KIAA1267; MSL1 homolog 1; MSL1v1; Non specific lethal 1 homolog; NSL complex protein NSL1; NSL1
Target Background
This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The encoded protein has been implicated in a variety of cellular processes including enhancer regulation, cell proliferation, and mitosis. Mutations in this gene are associated with Koolen-de Vries Syndrome.
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