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| Cat.No | ACP15615 | Target Name | DGKH |
|---|---|---|---|
| Target Synonyms | DGKHDiacylglycerol kinase eta; DAG kinase eta; EC 2.7.1.107; Diglyceride kinase eta; DGK-eta | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q86XP1 |
|---|
Uniprot Id
Q86XP1
Target Species
Human
Target Name
DGKH
Target Full Name
Diacylglycerol kinase eta
Target Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.
Target Subcellular Location
Cytoplasm. Cell membrane. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli (PubMed:12810723). Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association (PubMed:12810723). Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS (PubMed:19710016).
Target Protein Families
Eukaryotic diacylglycerol kinase family
Target Tissue Specificity
[Isoform 1]: Expressed only in testis, kidney and colon.; [Isoform 2]: Ubiquitously expressed.
Target Synonyms
DGKHDiacylglycerol kinase eta; DAG kinase eta; EC 2.7.1.107; Diglyceride kinase eta; DGK-eta
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