Recombinant Human THO complex subunit 6 homolog (THOC6)

Uniprot Id

Q86W42

Target Species

Human

Target Name

THOC6

Target Full Name

THO complex subunit 6

Target Function

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.

Target Involvement

Beaulieu-Boycott-Innes syndrome (BBIS)

Target Subcellular Location

Nucleus. Nucleus speckle.

Target Protein Families

WD repeat THOC6 family

Target Synonyms

THOC6; WDR58; PSEC0006; THO complex subunit 6 homolog; Functional spliceosome-associated protein 35; fSAP35; WD repeat-containing protein 58

Target Background

This gene encodes a subunit of the multi-protein THO complex, which is involved in coordination between transcription and mRNA processing. The THO complex is a component of the TREX (transcription/export) complex, which is involved in transcription and export of mRNAs. A missense mutation in this gene is associated with a neurodevelopmental disorder called Beaulieu-Boycott-Innes syndrome.