Recombinant Human Nitrilase homolog 1 (NIT1)

Uniprot Id

Q86X76

Target Species

Human

Target Name

NIT1

Target Full Name

Deaminated glutathione amidase

Target Function

Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.

Target Subcellular Location

[Isoform 2]: Mitochondrion.; [Isoform 1]: Cytoplasm.

Target Protein Families

Carbon-nitrogen hydrolase superfamily, NIT1/NIT2 family

Target Tissue Specificity

Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.

Target Synonyms

MGC57670 ; NIT1; NIT1_HUMAN; Nitrilase 1; Nitrilase homolog 1

Target Background

This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene.