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Recombinant Human Interleukin-34 (IL34)

ACP16197

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP16197 Target NameIL34
Target SynonymsC16orf77; Chromosome 16 open reading frame 77; FPT025; IL 34; IL-34; Il34; IL34_HUMAN; Interleukin 34; Interleukin-34; Interleukin34; MGC34647FormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Expression Range21-242
Protein LengthFull Length of Mature ProteinPurity>85% (SDS-PAGE)
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ6ZMJ4
Background Information
  • Uniprot Id

    Q6ZMJ4

  • Target Species

    Human

  • Target Name

    IL34

  • Target Full Name

    Interleukin-34

  • Target Function

    Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

  • Target Subcellular Location

    Secreted.

  • Target Protein Families

    IL-34 family

  • Target Tissue Specificity

    Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate

  • Target Synonyms

    C16orf77; Chromosome 16 open reading frame 77; FPT025; IL 34; IL-34; Il34; IL34_HUMAN; Interleukin 34; Interleukin-34; Interleukin34; MGC34647

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