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| Cat.No | ACP16583 | Target Name | SDE2 |
|---|---|---|---|
| Target Synonyms | SDE2; C1orf55; Replication stress response regulator SDE2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-451 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6IQ49 |
|---|
Uniprot Id
Q6IQ49
Target Species
Human
Target Name
SDE2
Target Full Name
Splicing regulator SDE2
Target Function
Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S-phase progression
Target Subcellular Location
Nucleus.
Target Protein Families
SDE2 family
Target Synonyms
SDE2; C1orf55; Replication stress response regulator SDE2
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