Recombinant Human Interleukin-23 receptor (IL23R), Truncated

Uniprot Id

Q5VWK5

Target Species

Human

Target Name

IL23R

Target Full Name

Interleukin-23 receptor

Target Function

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Target Involvement

Inflammatory bowel disease 17 (IBD17)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Type I cytokine receptor family, Type 2 subfamily

Target Tissue Specificity

Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.

Target Synonyms

IL 23R; IL-23 receptor; IL-23R; IL23 Receptor; Il23r; IL23R_HUMAN; Interleukin 23 receptor ; Interleukin-23 receptor

Target Background

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.