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| Cat.No | ACP17564 | Target Name | DEFB114 |
|---|---|---|---|
| Target Synonyms | DEFB114; DEFB14Beta-defensin 114; Beta-defensin 14; DEFB-14; Defensin; beta 114 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 27-69 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q30KQ6 |
|---|
Uniprot Id
Q30KQ6
Target Species
Human
Target Name
DEFB114
Target Full Name
Beta-defensin 114
Target Function
Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality.
Target Subcellular Location
Secreted.
Target Protein Families
Beta-defensin family
Target Tissue Specificity
Expressed in epididymis, predominantly in the caput (at protein level).
Target Synonyms
DEFB114; DEFB14Beta-defensin 114; Beta-defensin 14; DEFB-14; Defensin; beta 114
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