Recombinant Human Tripartite motif-containing protein 71 (TRIM71), Truncated

Uniprot Id

Q2Q1W2

Target Species

Human

Target Name

TRIM71

Target Full Name

E3 ubiquitin-protein ligase TRIM71

Target Function

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression.

Target Subcellular Location

Cytoplasm, P-body.

Target Protein Families

TRIM/RBCC family

Target Tissue Specificity

Specifically expressed in testis.

Target Synonyms

2610206G21Rik; Abnormal cell LINeage LIN 41; AL022943; E3 ubiquitin-protein ligase TRIM71; Gm1127; Homolog of C. elegans Lin 41; LIN 41; LIN41; LIN41_HUMAN; mlin 41; Protein lin 41 homolog; Protein lin-41 homolog; RGD1566388; Ripply2; TRIM 71; TRIM71; Tripartite motif containing 71; Tripartite motif-containing protein 71