Recombinant Human Eukaryotic translation initiation factor 3 subunit A (EIF3A), Truncated

Uniprot Id

Q14152

Target Species

Human

Target Name

EIF3A

Target Full Name

Eukaryotic translation initiation factor 3 subunit A

Target Function

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.; (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation.; (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.

Target Subcellular Location

Cytoplasm.

Target Protein Families

EIF-3 subunit A family

Target Synonyms

centrosomin homolog ; cytoplasmic protein p167; eIF 3 theta; eIF-3-theta; EIF3 ; eIF3 p167; eIF3 p170; eIF3 p180; EIF3 p180 subunit ; eIF3 p185; eIF3 theta ; eIF3a; EIF3A_HUMAN; EIF3S10 ; eukaryotic translation initiation factor 3 subunit 10 (theta 150 170kD) ; eukaryotic translation initiation factor 3 subunit 10 (theta 170kD); eukaryotic translation initiation factor 3 subunit 10 170kDa; Eukaryotic translation initiation factor 3 subunit 10; eukaryotic translation initiation factor 3 subunit 10 theta 150 170kDa; Eukaryotic translation initiation factor 3 subunit A; OTTHUMP00000020589; P167 ; p180 ; p185 ; TIF32

Target Background

Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and viral translational termination-reinitiation. Located in cytosol; nucleolus; and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex.